Gene TherapyWritten by Edward Tuddenham
Professor at University College London
Edward Tuddenham began working on factor VIII purification in 1976 at the University of Connecticut under Leon Hoyer and completed the task in 1982 with a small team at Royal Free Hospital, London. The purified protein was used in collaboration with Genentech to sequence the primary protein structure of factor VIII, clone the gene and achieve expression of active recombinant factor VIII by 1984.
He then set up an MRC funded research group, firstly at clinical science centre Northwick Park and subsequently at Imperial College Hammersmith, that cloned genes for several rare bleeding disorders, solved the structures of tissue factor and factor VII and set up the on-line database of mutations in haemophilia A.
From 2006 to 2011, he returned to Katharine Dormandy Haemophilia Centre with the aim of introducing gene therapy for haemophilia. This was successfully achieved in haemophilia B by December 2011.
He now works part time on gene therapies for haemophilia A and B.